A 'Kit' for increasing insulin production

ScienceDaily (July 17, 2012) ? Scientists from Western University in London, Canada and the Children's Health Research Institute, an Institute within the Lawson Health Research Institute, have identified the critical role of a receptor called c-Kit in the development and function of insulin-producing beta cells, making it an exciting therapeutic target for the management of diabetes.

The research, led by Rennian Wang, demonstrated that overexpression of c-Kit not only leads to increased insulin production but also counteracts the early diabetic effects of a high-fat diet. The paper and an accompanying commentary, are published in the August issue of Diabetologia, and featured in the Research Highlights in Nature Reviews Endocrinology (June 5).

Diabetes is one of the most common metabolic diseases affecting over 25 million Americans and 2 million Canadians. It's associated with a multitude of complications leading to considerable morbidity and a major medical as well as financial burden on society.

One of the major defects in diabetes is the loss of beta cells in the pancreatic islet. Wang and colleagues, including Zhi Chao Feng, a PhD candidate and first author on the paper, developed a transgenic mouse model (c-Kit Wv) which overexpressed c-Kit, specifically in beta cells. "When c-Kit is overexpressed, we observed a significant improvement in beta cell function and survival," says Wang, a Professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine & Dentistry. "You can even rescue c-Kit mutant mice from the early onset of diabetes, and protect against high-fat diet-induced beta cell defects. This is a novel finding and is being reported for the first time."

Wang believes ongoing research into c-Kit and its underlying mechanisms, will pave the way to develop strategies to preserve and restore function to beta cells as a cure for both type 1 and type 2 diabetes. This study was funded by the Canadian Institutes of Health Research.

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The above story is reprinted from materials provided by University of Western Ontario, via EurekAlert!, a service of AAAS.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/O-ZHy1GVCEc/120717162740.htm

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Dykstra pleads guilty in bankruptcy fraud case

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Source: http://news.yahoo.com/dykstra-pleads-guilty-bankruptcy-fraud-case-193030060--mlb.html

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Five Favorite Films with Hugo Weaving

Between playing Elrond in Lord of the Rings, voicing Megatron in Transformers and -- most memorably -- intimidating Keanu Reeves as the sinister Agent Smith in The Matrix, Hugo Weaving has been an integral part of three of the biggest film franchises of the past decade or so. The versatile Australian-born actor also delivered an uncanny Werner Herzog impression as Red Skull in Marvel's Captain America, will star in the Wachoswki's forthcoming Cloud Atlas and, of course, is reprising his role as Rivendell's boss elf in Peter Jackson's The Hobbit, due at the end of the year.

Yet being one of Hollywood's busiest character actors hasn't stopped Weaving from returning periodically to his homeland for some compelling lead roles, like that in this week's acclaimed Last Ride -- which has been hailed by no less than Roger Ebert as "the performance of a lifetime." A tough but ultimately moving (and beautifully lensed) road movie directed by Cannes' short film winner Glendyn Ivin, Ride has Weaving as a grizzled ex-con on the run across the Australian countryside, where he bond with his 10-tear-old son in tow. The film debuted to much praise in its native territory, and this week finds its way to select theaters in the US. We had the chance to speak with Weaving for the release, where he talked about five of his favorite movies.

My five favorite films would change from, you know, day to day, but if you want five of my favorite films, one would have to be The Rules of the Game, by Renoir. A fabulous upstairs-downstairs look at French society in a very particular period. It's both unbelievably sad and tragic, and moving and funny. And a delightfully humanist film. In fact, a lot of my favorite films are like that.

For instance, A Tree of Wooden Clogs, which would have to be one of my favorite films. A year in the life of a peasant commune in Italy -- again, it's poor souls living through a year, so you're getting a sense of seasons and hardship and community, and a simple, very basic deprived existence. I think that's a masterpiece, that film.

Closely Watched Trains, one of my all-time favorite films, by Jiri Menzel. Funny, wry, beautiful, entertaining; and subversive, in its own quirky way. A beautiful film.

If....

(Lindsay Anderson, 1968; 97% Tomatometer)

A film like If..... Lindsay Anderson's If...., which I think is a work of genius.

And Barry Lyndon. Anything by Kubrick. [Pauses] 2001... no... Barry Lyndon, yeah. If we're talking about Australian films, probably something like Ten Canoes. That's probably my favorite Australian film ever made, actually. I think it's a great, great film. I've probably listed more than five. And then there's 8 ?... I could go on forever. There are some great films coming to mind, like The Return, the Russian film. [Laughs] I'll stop.

Last Ride opens in select theaters this week and is available to watch now through VOD.

Source: http://www.rottentomatoes.com/m/1925468/news/1925468/

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First photo of shadow of single atom

Wednesday, July 4, 2012

In an international scientific breakthrough, a Griffith University research team has been able to photograph the shadow of a single atom for the first time.

"We have reached the extreme limit of microscopy; you can not see anything smaller than an atom using visible light," Professor Dave Kielpinski of Griffith University's Centre for Quantum Dynamics in Brisbane, Australia.

"We wanted to investigate how few atoms are required to cast a shadow and we proved it takes just one," Professor Kielpinski said.

Published this week in Nature Communications, "Absorption imaging of a single atom "is the result of work over the last 5 years by the Kielpinski/Streed research team.

At the heart of this Griffith University achievement is a super high-resolution microscope, which makes the shadow dark enough to see.

No other facility in the world has the capability for such extreme optical imaging.

Holding an atom still long enough to take its photo, while remarkable in itself, is not new technology; the atom is isolated within a chamber and held in free space by electrical forces.

Professor Kielpinski and his colleagues trapped single atomic ions of the element ytterbium and exposed them to a specific frequency of light. Under this light the atom's shadow was cast onto a detector, and a digital camera was then able tocapture the image.

"By using the ultra hi-res microscope we were able to concentrate the image down to a smaller area than has been achieved before, creating a darker image which is easier to see", Professor Kielpinski said.

The precision involved in this process is almost beyond imagining.

"If we change the frequency of the light we shine on the atom by just one part in abillion, the image can no longer be seen," Professor Kielpinski said.

Research team member, Dr Erik Streed, said the implications of these findings are far reaching.

"Such experiments help confirm our understanding of atomic physics and may be useful for quantum computing," Dr Streed said.

There are also potential follow-on benefits for biomicroscopy.

"Because we are able to predict how dark a single atom should be, as in how much light it should absorb in forming a shadow, we can measure if the microscope is achieving the maximum contrast allowed by physics."

"This is important if you want to look at very small and fragile biological samples such as DNA strands where exposure to too much UV light or x-rays will harm the material.

"We can now predict how much light is needed to observe processes within cells,under optimum microscopy conditions, without crossing the threshold and destroying them."

And this may get biologists thinking about things in a different way.

"In the end, a little bit of light just might be enough to get the job done."

###

Griffith University: http://www.griffith.edu.au

Thanks to Griffith University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121464/First_photo_of_shadow_of_single_atom

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Apple aware of corrupt apps issue, working on a fix

Earlier this morning, reports started circulating that the App Store was pushing corrupt binaries to iOS and Mac users, resulting in constant crashes of the affected apps. Marco Arment, of Instapaper fame, was one of the first to notice and very vocal -- bringing the issue to the attention of many in the media and at Apple. The list of affected apps is pretty staggering, including such high profile titles as Angry Birds Space, Yahoo! Search, Google Reader and, of course, Instapaper. The number of developers affected now tops 115, so we'd hold off on those updates. For the first several hours Apple was mum on the issue, but it has finally acknowledged the problem in the support forums and even reached out to developers via email. Suspicions seem to be that the FairPlay DRM is at the root, but until we have official word from Apple we'll refrain from laying the blame at its feet. Cupertino is working (we assume tirelessly) on a fix, which will hopefully be delivered sooner, rather than later.

Apple aware of corrupt apps issue, working on a fix originally appeared on Engadget on Thu, 05 Jul 2012 16:54:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/05/apple-aware-of-corrupt-apps-issue-working-on-a-fix/

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Japan ruling party defectors to form new party

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Source: http://news.yahoo.com/japan-ruling-party-defectors-form-party-092942552.html

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9/11 Memorial: Bloomberg Rejects Port Authority Control To 'Keep Out Of Political Process'

NEW YORK -- New York City Mayor Michael Bloomberg has rejected the Port Authority of New York and New Jersey's efforts to have a greater say over the 9/11 memorial.

The mayor said Monday control should remain with the National September 11 Memorial & Museum foundation to keep the site out of "the political process."

The mayor chairs the foundation. The Port Authority, controlled by the two state governors, owns the trade center site. The two sides have been feuding since last year, stalling the 9/11 museum's completion.

A spokesman for New Jersey Gov. Chris Christie said no one was interested in politicizing anything.

___

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Source: http://www.huffingtonpost.com/2012/07/03/911-memorial-bloomberg-port-authority-_n_1645619.html

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Limbaugh: It All Went Downhill When Women Got the Right to Vote (Little green footballs)

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Iran says it test-fires missiles in war of nerves

DUBAI (Reuters) - Iran said on Tuesday it had successfully tested medium-range missiles capable of hitting Israel as a response to threats of attack, the latest move in a war of nerves with the West.

Israel says it could attack Iran if diplomacy fails to secure a halt to its disputed nuclear energy program. The United States also has military force as a possible option but has repeatedly encouraged the Israelis to be patient while new economic sanctions are implemented against Iran.

The Islamic Republic announced the "Great Prophet 7" missile exercise on Sunday after a European embargo against Iranian crude oil purchases took full effect following another fruitless round of big power talks with Tehran.

Iran's official English-language Press TV said the Shahab 3 missile with a range of 1,300 km (800 miles) - able to reach Israel - was tested along with the shorter-range Shahab 1 and 2.

"The main aim of this drill is to demonstrate the Iranian nation's political resolve to defend vital values and national interests," Revolutionary Guards Deputy Commander Hossein Salami was quoted by Press TV as saying.

He said the tests were in response to Iran's enemies who talk of a "military option being on the table".

On Sunday, Iran threatened to wipe Israel "off the face of the earth" if the Jewish state attacked it.

Analysts have challenged some of Iran's military assertions, saying it often exaggerates its capabilities.

Senior researcher Pieter Wezeman of the Stockholm International Peace Research Institute said Iran's missiles were still relatively inaccurate and of limited use in conventional warfare. With conventional warheads, "their only utility is as a tool of terror and no more than that", he said by telephone.

He added, however, that they could be suitable for carrying nuclear warheads, especially the larger ones.

The International Institute for Strategic Studies, said in a 2010 report that all Tehran's ballistic missiles were "inherently capable of a nuclear payload", if Iran was able to make a small enough bomb.

Iran denies Western accusations that it is seeking to develop nuclear weapons capability. The world's No. 5 oil exporter maintains that it is enriching uranium only to generate more energy for a rapidly growing population.

OIL MARKETS ON EDGE

Iran has previously threatened to block the Strait of Hormuz, through which more than a third of the world's seaborne oil trade passes, in response to increasingly harsh sanctions by the United States and its allies intended to force it to curb its nuclear research program.

Fars said dozens of missiles involved in this week's exercises had been aimed at simulated air bases, and that Iranian-built unmanned drones would be tested on Wednesday.

Iran repeated its claim to be reverse-engineering the sophisticated U.S. RQ-170 drone that it says it brought down during a spying mission last year.

"In this drone there are hundreds of technologies used, each of which are valuable to us in terms of operations, information and technicalities," General Amir Hajizadeh was quoted by the ISNA news agency as saying.

Wezeman said Iran had a large standing armed force, but that its weapons were generally outdated. "And those weapons only get older and older and they don't have access to new technology because they are under a United Nations arms embargo."

In his first comments since the European Union oil ban took force, President Mahmoud Ahmadinejad said sanctions would benefit Iran by lessening its dependence on crude exports.

"We must see the sanctions as an opportunity ... which can forever take out of the enemy's hands the ability to use oil as a weapon for sanctions," Fars news agency quoted him as saying.

Negotiations over Iran's nuclear program continued in Istanbul on Tuesday with a meeting of technical experts from Iran and six world powers.

The discussions follow a round of political talks in Moscow last month at which the sides failed to bridge differences or agree on a further round of talks at that level.

The experts have no mandate to strike agreements but the six powers - the United States, China, Britain, Germany, France and Russia - hope that by clarifying technical aspects of Tehran's work they can open way for more negotiations in the future.

"We hope Iran will seize the opportunity of this meeting to show a willingness to take concrete steps to urgently meet the concerns of the international community," EU foreign policy chief Catherine Ashton said ahead of the meeting.

As a priority, the powers want Iran to stop enriching uranium to levels close to weapons-grade, ship out any stockpile, and close a secret facility where such work is done.

Iran denies its program has a military dimension and wants relief from economic sanctions before it makes any concessions.

IRANIAN CALL TO SHUT OIL LANES

On Monday, Iranian parliamentarians proposed a bill calling for Iran to try to stop tankers taking crude through the Strait of Hormuz to countries that support the sanctions.

However, the Iranian parliament is relatively weak, analysts say, and the proposal has no chance of becoming law unless sanctioned by Iran's clerical supreme leader.

That is seen as unlikely in the near term given that Western powers have said they would tolerate no closure of the Strait while Iranian leaders, wedded to strategic pragmatism for the sake of survival, have said they seek no war with anyone.

"It's a gesture at this stage," said independent British-based Iran analyst Reza Esfandiari.

"They want to emphasize that Iran can make life difficult for Europe and America. I think this is more of an attempt to offset falling crude prices. Financial markets are very sensitive to such talk."

On Tuesday, the price of Brent crude, which has been on a downward trend for the last three months, broke $100 for the first time since early June.

"A lot depends on nuclear talks," said Esfandiari. "If there's no progress and the initiative is deadlocked, then these kind of actions will intensify."

(Additional reporting by Yeganeh Torbati in Dubai, Fredrik Dahl in Vienna and Justyna Pawlak in Brussels; Editing by Mark Heinrich and Kevin Liffey)

Source: http://news.yahoo.com/iran-test-fires-medium-range-missiles-111829434.html

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WHO probing child deaths from unknown disease in Cambodia

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Source: http://news.yahoo.com/probing-child-deaths-unknown-disease-cambodia-092138372.html

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Kobo eReader Touch up for pre-order in Japan, hitting market with 'localized experience' July 19th

Ever since Rakuten revealed its intentions to scoop up Kobo, the e-reader maker was clearly destined to hit the Japanese market. As noted a week or so back, the company's eReader Touch will be arriving the Land of the Rising Sun in July -- July 19th, to be exact. And, starting today, customers in that country can pre-order the reader for ¥7,980 (or $100 USD). Kobo's promised a "fully localized" experience on the reader, including local currency, content and a "robust" offering of Japanese books in time for launch.

Continue reading Kobo eReader Touch up for pre-order in Japan, hitting market with 'localized experience' July 19th

Kobo eReader Touch up for pre-order in Japan, hitting market with 'localized experience' July 19th originally appeared on Engadget on Mon, 02 Jul 2012 14:32:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/02/kobo-ereader-touch-up-for-pre-order-in-japan-hitting-market-wit/

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